If ingested, seek medical advice immediately and show the container or the label. Sodium metabisulfite 2 x 500 mg supporting information. Bisulfite conversion was one of the first techniques developed for methylation analysis and is still considered the gold standard 21 because it allows for quantitative comparisons of methylation levels at singlebase resolution. Allow to stand for 5 minutes, protected from light, add 1 ml of hydrochloric acid, and titrate the excess iodine with 0. Sodium laurilsulfate european pharmacopoeia ep reference standard synonym. Sodium bisulfite sodium bisulfite reduces free chlorine to sodium bisulfate and hydrochloric acid. These offers over 300 food grade chemical ingredients packaged in laboratory size bottles to production drum quantities and. Pdf a stability indicating method for the determination of. Nf similar structures search, synonyms, formulas, resource links, and other chemical information.
S654500 casno 7631905 synonyms sodium hydrogen sulfite recommended use laboratory chemicals. Antioxidants are excipients that are used to improve the stability of medicines by delaying the oxidation of active substances and other excipients and are classified into 3 groups 4. Safety data sheet creation date 14may2010 revision date 17jan2018 revision number 6 1. Uses advised against not for food, drug, pesticide or biocidal product use details of the supplier of the safety. Sodium bisulfite sb is an inorganic compound commonly used as an antioxidant in pharmaceutical formulations. Sodium sulphite bp ip sodium sulfite usp nf acs fcc. Sodium sulphite bp ip sodium sulfite usp nf acs fcc manufacturers. Potassium sulfate, sodium acetate hydrate, sodium bisulfite, sodium carbonate.
Mix, heat until effervescence ceases, and dilute with ml of water. To prevent oxidative decomposition of dexamethasone phosphate in 40 aqueous solution sodium metabisulfite is used as an antioxidant. The method described herein separated sodium bisulfite from all other formulation components. Moreover, sb is not officially represented in any pharmacopoeia to date. Sodium bisulfite solution safety data sheet according to u. Sodium bisulfite is a white crystalline powder and has an odor like that of sulfur dioxide. Identification a solution 1 in 20 responds to the tests for sodium 191 and for sulfite 191. It is a chemical compound that is used as a food additive, mostly in commercial wine to reduce oxidation and preserve the aromas and flavors. Sodium disulfite is an inorganic sodium salt composed of sodium and disulfite ions in a 2.
Add 140 ml of 1n sodium of ferrous ammonium sulfate in 20 ml of water, and add 1 hydroxide and 50 ml of water. The chloramines are converted to sodium bisulfate, hydrochloric acid, and ammonium chloride. Chapter3 quantitation of sodium bisulfite in pharmaceutical. Dijkstra and dekker 1 reported 41 the addition of bisulfite at the c1 of. Sodium metabisulfite appears as a white crystalline or powder solid with a slight sulfur odor. It is acidic, considered corrosive, and is a powerful reducing agent used in water. It is so irritating that contact cannot be tolerated. Notereserve portions of the solution so obtained for use in identification test b and in the test for color and clarity of solution.
Water guard provides sodium bisulfite in a 38%40% nonfood grade solution for use in the dechlorination of process and wastewater applications. Assay transfer about 200 mg of sodium metabisulfite, accurately weighed, to a glassstoppered conical flask containing 50. Antioxidants are excipients that are used to improve the stability of medicines by delaying the oxidation of active substances and other excipients and are classified into 3 groups. Technical bulletin sodium bisulfite sodium bisulfite is a yellowishwhite solution with a strong pungent so2 odor. The oral ld50 in rats fed this substance is 2 gkg dow chemical company 1977d, as cited in acgih 1986ex. Its natural form is a white crystalline powder, but turns yellow in solution. Sodium disulfite, sodium pyrosulfite cas number 7681574. It is a white solid with an odor of sulfur dioxide. You can see this in the formulas sodium sulfite is the disodium salt, and bisulfite is the sodium hydrogen salt. A horizontal line in the margin indicates where part of a text has been deleted. Sodium bisulfite dna treatment allows for discrimination between methylated and unmethylated cytosines. Any unpermitted introduction of this product into a facility. The classical, manual method of iodometric determination reich, 1961 is stil widely.
Sodium bisulfite is typically used as an aqueous solution. Pdf a stabilityindicating reversedphase highperformance liquid. Where sulfur dioxide or liquid aerosol mists are generated and cannot be controlled to within acceptable levels, use appropriate nioshapproved respiratory protection equipment combined 42 cfr 84 class n, r or p95 or p100 particulate filter. Ph eur find msds or sds, a coa, data sheets and more information.
Sodium bisulfite in contact with chlorine bleach aqueous solution of sodium hypochlorite will release harmful fumes. List of united states pharmacopoeia usp analytical reference standards of sodium metabisulphite and related impurities. Acute poisoning from sulfur dioxide is rare because the gas is easily detected. Sodium bisulfite 7631905 4010 % sodium sulfite 7757837 sodium bisulfite or meta bisulfite can provide sodium, hydrogen and sulfite ions. The authors of a paper that appeared in the august 2015 issue of the journal of food composition and analysis found that sodium bisulfite lowers the thiamine content of rice. American elements produces to many standard grades when applicable, including mil spec military grade. It is also called sodium hydrogen sulfate, and is classed as a sulfite, or sulfurbased chemical.
Sodium bisulfite is a food additive with e number e222. Sodium metabisulfite united states pharmacopeia usp reference standard. Uses advised against not for food, drug, pesticide or biocidal product use. General pharmacopoeia monograph pharmaceutical forms gpm.
Sodium bisulfite naho3s or nahso3 or hnao3s cid 23665763. Dexamethasone sodium phosphate injection is a sterile solution of dexamethasone 58 sodium phosphate in water for injections. Assay transfer about 250 mg of sodium sulfite, accurately weighed, to a 500ml beaker, add 50. Pdf a stability indicating method for the determination. Allow to stand for 5 min, add 1 ml of hydrochloric acid, and titrate the excess iodine with 0. The international pharmacopoeia world health organization. Sodium disulfite cas 7681574 sodium metabisulfite for analysis emsure acs,reag. Sodium bisulfite is generally immediately available in most volumes. Sodium bisulfite in fact is not a real compound, but a mixture of salts that dissolve in water to give solutions composed of sodium and bisulfite ions. Symptoms include coughing, hoarseness, sneezing, tearing, and breathing difficulty. Chemical properties of sodium bisulfate petitioned, sodium sulfate and sodium bisulfite similar. Bisulfite sequencing provides single base resolution for analysis of dna methylation patterns 24. Sodium bisulfite nahso3 is a weakly acidic compound that is usually used as a mild reducing agent.
Optical grade, usp and epbp european pharmacopoeia british pharmacopoeia and. Titrate the hot solution with carbonatefree sodium hydroxide 1 moy1 vs, using phenolphthaleinethanol ts as indicator. A common application is in the workup of reactions involving bromine or iodine. October 26, 2009 sodium bisulfite solution page 3 of 4 respirators. Sodium bisulfite, granular, fcc is used as an antioxidant to preserve the aromas and flavors. Sodium bisulfite appears as white crystals or crystalline powder. Depending on the ph of the solution, which can be adjusted by any of the standard technique, the bisulfite ion is at equilibrium with sulfurous acid or sulfite. Che1090s 29 contact lenses, if present and easy to do.
The hazard fields include special hazard alerts air and water reactions, fire hazards, health hazards, a reactivity profile, and details about reactive groups assignments and potentially incompatible absorbents. Many people consider sodium bisulfite harmless, but this food additive can have unexpected effects. Sodium bisulfite or sodium bisulphite, sodium hydrogen sulfite is a chemical mixture with the approximate chemical formula nahso 3. Sodium metabisulfite united states pharmacopeia usp reference standard synonym. Pdf a stability indicating method for the determination of the. Sodium metabisulfite united states pharmacopeia usp. Sodium bisulfite, granular, fcc, panreac msds, coa. Dodecyl sodium sulfate, dodecyl sulfate sodium salt, lauryl sulfate sodium salt, sds, sodium dodecyl sulfate, sodium lauryl sulfate cas number 1512. Noncombustible, but may decompose to emit toxic oxide fumes of sulfur and sodium when heated to high temperature. Validation of microbial recovery from disinfectants. Sodium bisulfite, granular, fcc is also referred to as sodium hydrogen sulfite. Sodium hydrogensulfite is an inorganic sodium salt and a sulfite salt. Since you have the acid salt form of sulfite, the ph is lower, and thats why you are driving sulfite as.
The basis of sodium bisulfite sequencing is the fact that cytosine is deaminated to uracil by sodium bisulfite but 5methylcytosine is resistant to bisulfiteinduced deamination 2123. Never give anything by mouth to an unconscious person. Sodium laurilsulfate european pharmacopoeia ep reference. The information in the summary is basic information and is not intended to provide emergency response information, medical information or treatment information. Perform a blank determination see residual titrations under titrimetry 541, and make any necessary correction. Sodium metabisulfite united states pharmacopeia usp reference. However, these indications, which are not necessarily exhaustive, are given for. Chemically, sodium bisulfite is a combination of sodium, hydrogen, sulfur and oxygen. Aluminium hydroxide, hydrated, for adsorption 1798. This salt of bisulfite can be prepared by bubbling sulfur dioxide in a solution of sodium carbonate in water. The fcc grade meets the requirements of the food chemical codex indicates and is suitable for all food, beverage and nutritional supplement applications. Sodium disulfite cas 7681574 106528 merck millipore. Used as a food preservative and as a laboratory reagent.
Dechlorination of disinfected wastewater should be practiced to prevent. High purity, submicron and nanopowder forms may be considered. A stability indicating method for the determination of the. Ac223070000, ac223070010, ac419440000, ac419440010, ac419440025, ac419440050 ac419440050, ac41944, s6543, s6543lc, s654500 synonyms. Sodium bisulfite solutions may release toxic and hazardous fumes of sulfur oxides, including sulfur dioxide. Sodium metabisulfite is available commercially in several gradesfood and. If large quantities of this material are swallowed, call a physician immediately.
A stability indicating method for the determination of the antioxidant sodium bisulfite in pharmaceutical formulation by rphplc technique. Sodium sulfate is also 68 included for comparison, as it is often confused with sodium sulfite although they are distinctly different 69. In case of insufficient ventilation, wear suitable respiratory equipment. This product contains one or more components designated as hazardous substances or toxic pollutants pursuant to the federal clean water act 40 cfr 116. Sodium bisulfite or metabisulfite provides mostly bisulfite ion and sodium ion in a dilute solution. Prepare amifor the preparation of test solutions, use reagents of the nonaphtholsulfonic acid ts fresh on the day of use by dis.